Abstract
We examined the action mechanism of Tranilast (N-5') in secretory otitis media (SOM). Tranilast and the derivatives were detected in middle car effusion (MEE) of patients treated with Tranilast for 1 to 3 weeks. The levels of C3a and C5a in MEE were significantly high in all cases of SOM, but decreased with the duration of Tranilast treatment. When MEE was incubated with Tranilast at 37°C for 1 hr, the levels of C3a and C5a decreased. These results indicate that C3a and C5a are associated with SOM, and that Tranilast transfered into MEE decreases the levels of C3a and C5a, leading to improvement of SOM.
