抄録
Cisplatin resistance was examined with the use of KB cells and KB-rc cells (cisplatinresistant KB cells). Their viability under the influence of cisplatin and verapamil was determined with trypan blue staining. Verapamil reinforced the effect of cisplatin on both KB cells and KB-rc cells. In a study of cell kinetics with flow cytometry S phase accumulation was observed when verapamil was added to cisplatin. The Ca channel blocker, verapamil increases the effect of cisplatin.
