1995 年 88 巻 12 号 p. 1655-1663
The efficacy, safety and usefulness of ketotifen nasal spray was investigated in 20 children with mainly serous allergic rhinitis. Many of them had complications of atopic dermatitis and/or bronchial asthma, and had not responded to previous treatment. In this study, ketotifen nasal spray (0.05mg/puff) was given 2-4 times daily (0.2-0.4mg/day) for 4 weeks or longer. The percent efficacy and usefulness of ketotifen nasal spray were 55.0% and 55.0%, respectively, and clinical signs were considerably improved. Regarding the safety, there were no patients showing adverse reactions. These results showed that ketotifen nasal spray is a very effective and safe treatment for allergic rhinitis in children.