口腔咽頭乾燥症へのツムラ麦門冬湯の効果

抄録

A multicenter study was carried out in 24 institutions in Kanagawa prefecture. The subjects were 113 male and 145 female patients, ranging in age from 28 to 86 years (mean 63.7), who complained of dryness of the mouth and throat. The following illnesses were diagnosed: xerostomia and pharyngoxerosis in 161; radiation xerostomia and pharyngoxerosis in 56; chronic pharyngitis with dry mouth and throat in 22; and Sjögren's syndrome in 7; 11 patients had other symptoms. The subjects were given a 3-gram pack of granules of Tsumura Co's Bakumon Doto extract three times a day before each meal. Their subjective symptoms and objective signs were examined prior to administration and two and four weeks after the beginning of therapy.
1. Overall improvement rates: There was significant improvement in 11%; moderate improvement in 31%; slight improvement in 35%; no change in 23%; and worsening in 1%.
2. Patients' impressions: Significant improvement; moderate improvement by 35%, some improvement by 28%, and no change by 24%.
3. Time of appearance of effect: Of those patients who experienced changes in their symptoms, 15% experienced them during the first week, 74% by the end of the second week, 78% by the end of the third week, and 100% by the end of the fourth week.
4. Overall improvement rates according to illness: Of those patients whose symptoms were significantly or somewhat reduced, 68% of those with chronic pharyngitis said that the medicine was effective; 42% of those with xerostomia and pharyngoxerosis; 30% of those with radiation xerostomia; and 14% of those with Sjögren's syndrome.