A 55-year-old female presented with headache and aphasia of the department of neurosurgery in our hospital. On CT examination, the patient had an enhanced ring in the temporal lobe, and inflammation reaction was higher than normal levels, and the neurosurgeon diagnosed an intracranial abscess. Chemotherapy was begun on admission together with the administration of an anti-convulsant. After one month, aural discharge was noted, and we diagnosed intracranial abscess due to middle ear inflammation. The aural CT scan was revealed bone destruction and we noted cholesteatoma in the mastoid. We performed mastoidectomy and neurosurgeons removed an abscess capsule by craniotomy. The patient was discharged on the 26th postoperative day. Recently, otologic treatment for an otogenic intracranial abscess is often delayed because of the initial treatment by other specialists. In the present case, we speculated that the initial absence of aural discharge was due to the intensive chemotherapy.