The Effect of Mosapride Citrate on Patients with Non-Erosive Reflux Disease (NERD)

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Gastroesophageal reflux disease (GERD) has been known to cause pharyngeal symptoms such as globus pharyngeus, cough, hoarseness and swallowing disturbance. Non-erosive reflux disease (NERD) is thought to be more difficult to treat than erosive reflux disease (e-GERD) due to the high prevalence of proton pump inhibitor (PPI) resistance. Mosapride citrate improves gastrointestinal peristalsis by promoting the acetylcholine isolation in the gastrointestinal nerve plexus.
We administrated mosapride citrate for 4 weeks in 22 patients with NERD who were diagnosed with the laryngoscope and upper gastrointestinal endoscopy, and the subjective symptoms were assessed on a frequency scale for the symptoms of GERD (FSSG). The overall symptom improvement degree was 68.2%, which was approximately equal to other reports. Mosapride citrate improved both the acid reflux-related scores and the dyspeptic symptom scores on FSSG.
We concluded that mosapride citrate is effective on some patients with NERD.