1986 Volume 1986 Issue Supplement8 Pages 161-172
Twenty-eight cases with severe vestibular impairment who visited the Department of Otorhinolaryngology, Yamaguchi University School of Medicine from 1975to 1985 were studied otoneurologically. Cases of vestibular impairment were as follows: 22 cases due to drug intoxication (Streptomycin sulfate 16, combined Streptomycin 3, Gentamicin 1, Sisomicin 1 and Amikacin 1),1 of Harada's disease (uveomeningitic syndrome),1 of bilateral vestibular neuronitis,1 of bilateral acoustic neurinoma,1 of suppurative meningitis and 2 due to unknown cause.
Of 22 cases due to drug intoxication, only one case show ed marked recovery of caloric response by 6 months.
Subjective prognosis was fairly good in 8 out of 15 cases due to Streptomycin sulfate intoxication.
Caloric response at the early period after the manifestation of dysequiliblium is considered as an important indicator determining the prognosis in case with severe vestibular impairment.
