1986 Volume 1986 Issue Supplement8 Pages 63-67
We investigated the location of immunogloblin G (IgG) in the endolymphatic sac (ES) of guinea pigs to prove the one of evidences that ES will be the involved organ in immuno-reaction of the inner ear. By using immunohistological technique we could recognize IgG mainly in the subepithelial layer of ES and partially in some ES epithelium. Free floating cells also have IgG. Plasma cells that will exist in the subepithelial layer could not clearly recognized as having IgG.
These results might indicate that ES can be an immunor e active organ of the inner ear under some pathlogical conditions and that the origin of IgG in the ES will be mainly derived from the systemic source.
