1991 Volume 1991 Issue Supplement48 Pages 67-73
Histological effects of combination chemotherapy including CPAF (a combination of CDDP, PEP, THP-ADM and 5-Fu) regimen as neo-adjuvant chemotherapy were studied in 9 cases of squamous cell carcinoma of the tongue. The clinical effect, was CR in 7cases, PR in 2 cases. The response rate was 100%. Histologically,4 cases were classified as Grade IV Change,2 cases as Grade III change,2 cases as Grade IIa and IIb change according to the classification of Ohboshi-Shimozato.
Side effects were recognized in all cases. Nausea, vomiting and alopecia were the most common (88.9%).
The decrease of WBC counts below 3000 /mm3 was observed in 4 cases and was mostly transient.
These results indicate that the CPAF regimen as neo-adjuvant chemotherapy is effective, not only for the palliative treatment of squamous cell carcinoma of the tongue, but also for the reduction of tumor bulk.
