三重癌10症例の臨床的検討

抄録

We experienced 679 cases of head and neck cancers between 1978 and 1991. Among them,10 cases were triple primary cancers. We studied these 10 triple cancer cases with regard to the incidence, primary organs, intervals, risk factors, and prognosis. The incidence of triple primary cancers was 1.47%, and 9 were in males and one in a female. The mean age at the time of the first primary cancer occurred was 63.2 years old. The oral cavity and esophagus were the most frequently involved (70%) as a prim a ry region. With regard to the intervals, the average between first and second cancer, and between second and third cancer were 2 years and 8 months respectively. As risk factors of multiple primary cancers, Brink man Index and Sake Index were 651and 80, respectively. The prognosis of triple primary cancers was very poor and the average of the periods from the third primary cancer to death was 7 months. In this investigation, we emphasized the im portance of early diagnosis and treatment for the multiple cancers.