1993 Volume 1993 Issue Supplement68 Pages 133-139
A case of Werner's syndrome associated with malignant tumor in the nasal cavity is reported with some consideration of the literature. The patient, a 32-year-old female, complained of left nasal obstruction and hemorrhagic nasal discharge. A tumor was found in the left nasal cavity. Histopathological study showed squamous cell carcinoma. Clinical manifestations included senile face, bilateral cataracts, sclerodermia-like signs, short stature and low body weight, osteoporosis and diabetes mellitus. She was diagnosed with Werner's syndrome and treated with radiotherapy and surgery.
It is well known that this syndrome is characterized by a high frequency of malignant tumors. This is the 5th report describing Werner's syndrome associated with malignant tumor of the nasal cavity in Japan.
