単離前庭1型感覚細胞形態に対するニトロプルシドの影響

抄録

The purpose of this study was to investigate the effects of sodium nitroprusside (SNP) on isolated type I vestibular hair cell morphology. Vestibular hair cells were superfused with artificial perilymph containing SNP. Application of 3 or 30 mM SNP resulted in a high rate (50 and 33%, respectively) of bleb formation in the neck region and decreased (3 mM,5.4%; 30 mM,8.0%)mean cell length. This bleb formation and neck shortening may alter the ability of mechanotransduction and was suggested to disrupt mechanotransduction in the vestibule.