抄録
Asp-Ile-Leu-Arg-Gly-NH2 (DILRG-NH 2), a pentapeptide with amidated C-terminus, has been isolated from diapausing pharate first instar larvae of the wild silkmoth Antheraea yamamai. In this study, we examined effects of this peptide and three related compounds on the proliferation of rat hepatoma cells and mouse spleen lymphocytes. The amidated pentapeptide and its truncated version ILRG-NH2, not LRG-NH2 and the non-amidated pentapeptide, suppress proliferation of the rat hepatoma cells. This suppression may be due to a cell cycle arrest rather than to an apoptotic/necrotic activity. Amino acid residues 2-5 and carbonyl amidation appear essential for its activity. The results indicate that the isolated pentapeptide is a candidate for therapeutic use.
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