Interdiffusion in the Al-2.07at%Ag alloy was investigated under high pressure up to 3.24 GPa at the temperature range from 698K to 897K. The interdiffusion coefficients, activation energy and volume were determined. The diffusion coefficients decrease with pressure, while activation energy increases with pressure. The activation volume of interdiffusion is 7.77.8×10-6m3/mol at the temperature range from 783K to 897K. The calculated activation volume of impurity diffusion of Ag in Al is 8.08.1×10-6m3/mol. It is suggested from the fact that the Ag diffusion in Al is dominated by the single vacancy mechanism in the temperature range from 783K to 897K.