Abstract
The number of patients with diabetes mellitus and people with prediabetes has been rapidly increasing due to changes in life style and social environment in Japan. Type 2 diabetes, found in the majority of diabetes patients, is seen as a major cause of swelling healthcare cost. Therefore, the prevention of its onset and initial treatment are essential.
In recent years, it has been reported that many probiotics are effective in some diabetic animal models. However, the mechanism of their action is not clear, due to the complicated mechanism of the onset and exacerbation of type 2 diabetes itself. In this paper, we describe a possible mechanism of probiotic actions against diabetes such as improved fat metabolism, anti-inflammatory effects, and improvement of gut microbiota, and probiotics beneficial role in initial treatment and prophylaxis of diabetes.
