Abstract
Recent studies of microbiota have indicated that gut microbiota might play an important role in the pathophysiology of irritable bowel syndrome (IBS). IBS is initiated by acute bacterial infection of the gut (post-infectious IBS). The composition of gut microbiota in IBS patients differs from that in healthy controls. Mimicking the features of IBS, psychosocial stress alters the composition of gut microbiota, increases mucosal permeability, and sensitizes visceral nociception. Not only IBS symptoms but also negative emotions, including depression, have been reported to be improved by interventions with oral administration of probiotics. Fecal concentrations of acetate and propionate are related to gastrointestinal symptoms, quality of life, and factor 3 of alexithymia. Continuing research into the role of gut microbiota in IBS is warranted.
