A Cross-sectional Study on the Relationship between Nutrient/Food Intake and Gut Microbiota in Frailty among Older Community Residents: The Kyotango study

Abstract

We presented the results of an analysis on frailty status and its risk factors among elderly residents participating in the Kyotango longevity cohort. Compared to the non-frail group, the frail group showed significantly lower intake of nutrients such as plant-based protein, minerals including potassium (K) and magnesium (Mg), B vitamins, and dietary fiber. Among food groups, soybeans and soybean products were identified as being significantly less consumed in the frail group. Cluster analysis examining the correlation between diet, nutrient intake, and gut microbiota identified key bacterial genera, including Eubacterium eligens, Christensenellaceae R-7, and UCG-002. The study highlighted the potential of detailed analyses of the relationships between diet, nutrient intake, and the gut microbiota in contributing to frailty prevention, incorporating the latest research findings.