SIRS改善後も(1→3)-β-D-グルカンの異常高値が持続した多発外傷の1例

抄録

We report the case of a 28 year-old man with multiple trauma who had persistently high serum levels of (1→3)-β-D-glucan (7, 400pg/ml) even after the state of systemic inflammatory response syndrome (SIRS) subsided. This finding suggests that the serum level of (1→3)-β-D-glucan dose not always reflect the state of illness nor serve as a guide for treatment. This case did not show any findings of intestinal fungal infection, but the state of SIRS subsided after enteral medication of amphotericin B. Several oral medications and enteral diets were found to contain a significant amount of (1→3)-β-D-glucan, so we hypothesized that fungi or (1→3)-β-D-glucan had translocated from the intestines to the blood.