緩衝溶液中の共存カチオン・アニオンとリン酸八カルシウム(OCP)形成性

抄録

This paper details the results of the previous research on the fabrication of octacalcium phosphate (OCP)-based bone substitute materials, along with its new findings. OCP has received considerable attention as a new bone substitute material because it exhibits excellent biocompatibility. However, its poor formability seriously restricts its implementation in biomedical applications, especially as a bone substitute. OCP has been fabricated in aqueous solution via aqueous mediated reactions. Furthermore, the crystal growth process of OCP as a bone substitute material has also been investigated. Although previous studies have indicated that OCP is preferentially formed under weak acidic solutions, we also introduced Na⁺ and PO₄³⁻ as key factors for OCP formation because they strongly enhance the OCP crystal structure. Based on these new findings about OCP formation, we introduced fabrication protocols for an OCP block as a bone substitute. In vivo studies have indicated that the fabricated OCP block exhibits excellent biocompatibility.