Age-related deterioration of contractile activity of actomyosin complex in rat gastrointestinal smooth muscle

抄録

It was found, that in rat senile age group, a decrease in the ATPase activity of actomyosin leads to deterioration of motility of stomach and colon with aging. White outbred rats aged 3 and 22–24 months were used. An amount of cleavage inorganic phosphate from ATP by myosin active centers was quantified to define the ATPase activity of actomyosin. It was established that Mg²⁺, Ca²⁺, K⁺-ATP-hydrolase activity of actomyosin in smooth muscle of rat stomach decreases as well as in colon. The observed deterioration of contractile activity of actomyosin complex can be explained by revealed oxidative modification of contractile proteins.