計量生物学
Online ISSN : 2185-6494
Print ISSN : 0918-4430
総説
連続再評価法とその周辺(I)—連続再評価法とは—
大門 貴志
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ジャーナル フリー

2012 年 33 巻 1 号 p. 1-29

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A number of designs of phase I dose-finding trials have been developed. Algorithm-based designs such as standard 3 + 3 designs are easy to understand and implement since they do not require explicit model specification for a dose-toxicity relationship. On the other hand, model-based designs such as the continual reassessment method (CRM) (O’Quigley et al., 1990) have been proposed. The author will give a review of the CRM and its related topics. In particular, the author makes mention of some of the problems with 3 + 3 designs that have often been used in phase I dose-finding studies and gives a detailed description of ideas, concepts, theories, properties and issues in the CRM.

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© 2012 日本計量生物学会
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