Abstract
We investigated the relationship between insulin resistance and remnant-like particle cholesterol (RLP-C) using 472 subjects (174 men and 298 women) randomly selected from inhabitants of two rural communities in Japan, Tanno and Sobetsu. Fasting immunoreactive insulin (FIRI), fasting blood glucose (FBS), total cholesterol (TC), triglyceride (TG), HDL cholesterol, LDL cholesterol, and RLP-C were measured in each subject. HOMA-R was used as an indicator of insulin resistance. The subjects were divided into two groups according to the value of HOMA-R : an insulin-resistance (IR) group consisting of subjects with HOMA-R≥ 1.73 and a normal (NR) group consisting of subjects with HOMA-R < 1.73. There was a significant positive correlation between HOMA-R and RLP-C. The value of RLP-C was higher in the IR group than in the NR group (5.9 mg/dl vs. 3.6 mg/dl). The frequency of hyper RLP cholesterolemia (RLP-C ≥7.5mg/dl) was higher in the IR group than in the NR group (21.7% vs. 4.8%). The results of multiple regressionanalysis showed that HOMA-R was closely related to RLP-C. The results of this study suggest that RLP-C is closely associated with atherosclerosis in insulin-resistance syndrome.
