Abstract
A case was 81-year-old woman with gastrointestinal stromal tumor (GIST) of stomach accompanied by liver metastases, who underwent partial gastrectomy and hepatectomy. Multiple liver metastases were diagnosed 8 months after R0 surgery. While metastases disease was well controlled with administration of imatinib for 4 years, gastric cancer in remnant stomach was diagnosed. Total gastrectomy was undergone, pathological findings were that well differentiated tubular adenocarcinoma cells were localized in mucosa and no lymph node metastases was found but local recurrence of GIST was pointed out. One month after total gastrectomy, she resumed administration of imatinib and she has no sign of progression with neither gastric cancer nor GIST. Only 11 synchronous GIST cases of 685 gastric cancer cases were found and it is first case for our institution that gastric cancer was occurred during imatinib therapy for recurrence GIST. But secondary cancer should be concern because of long survival time for unresectable metastases GIST patients with imatinib.
