Abstract
A 66-year-old man presented with abdominal distention. Abdominal computed tomography (CT) showed a huge tumor 25cm in diameter that was suspected to directly invade the transverse colon and the pancreas. The patient was given neoadjuvant chemotherapy with imatinib (400mg/day) to reduce the risk of surgery and to promote functional preservation. After 24 weeks of treatment, CT revealed massive degeneration of the tumor. Sleeve resection of the stomach with partial resection of transverse colon was performed. The tumor invaded only the transverse mesocolon, and curative resection was possible without rupture. The patient postoperatively received adjuvant chemotherapy with imatinib, and there has been no evidence of recurrence as of 18 months after surgery.