Two Patients with Localization-related Epilepsy Showed Reversed Redistribution on ¹²³I-IMP SPECT

Abstract

Two patients with localization-related epilepsy showed reversed redistributions of ¹²³I-IMP on SPECT examinations which were carried out within a few hours after seizures. Re-examinations in seizure free periods failed to yield the reversed redistribu tions in both patients. It is most probable that a postictal abnormality of the cortical tissue retains IMP at the epileptogenic focus and this IMP retention mechanism reveals the postictal abnormality as reversed redistribution on SPECT.
In either patient, the localization of reversed redistribution was congruent with the epileptogenic focus determined by EEG or MRI findings. It should be useful to carry out ¹²³I-IMP SPECT within a few hours after the seizures to determine the localization of the epileptogenic focus.