Abstract
It is considered that1H magnetic resonance spectroscopy (1H-MRS) values reflect the pathological conditions on both the epileptic focus side and non-focus side of temporal lobe epilepsy (TLE). Twenty-two adults (eleven men and women) with TLE were studied about the correlation between MRS values and psychiatric symptom scales. N-acetylaspartate/choline+creatin (NAA) and choline/creatin (Cho) values were measured in the bilateral mesial temporal lobes. The psychdatric symptom scales were evaluated by Hopkins Symptom Checklist 90-Revised (SCL). Many scales of psychiatric symptoms such as depression and paranoid ideation shown by SCL negatively correlated with NAA values and positively with Cho values significantly. The NAA and Cho values in the left side were more correlated than those in the right side with mental symptom scales, which was shown markedly in Cho. Besides, decrease of NAA value was correlated significantly with secondarily generalized tonic clonic seizures among clinical factors.
