Abstract
A 44-year-old woman presented with right upper quadrant pain and fever. A preoperative diagnosis of gastrointestinal stromal tumor of the duodenum was made by CT. Removal of the tumor, cholecystectomy, and partial resection of the stomach and duodenum was performed. Retroperitoneal extraskeletal osteosarcoma accompanied by malignant fibrous histiocytoma and liposarcoma, was diagnosed upon histopathological examination. After postoperative adjuvant chemotherapy for osteosarcoma, the tumor recurred 3 times to the stomach, superior border of the pancreas and the liver, respectively, but they were resected surgically each time. The patient is free from the tumor 7 years after the first operation.