2016 Volume 49 Issue 4 Pages 293-300
An 84-year-old man had been found to have a massive cystic lesion in the pancreatic body 25 years prior to the current presentation and underwent spleen-preserving distal pancreatectomy. The lesion was pathologically diagnosed as a solid-pseudopapillary neoplasm (SPN). The patient experienced multiple recurrences at 7, 10, 11 and 20 years after the first surgery and underwent tumor resection each time. He complained of postprandial abdominal distention 2 years after the 4th surgery (22 years after the first surgery). Detailed examination revealed a cystic mass approximately 10 cm in size with a lobulated multilocular structure at the pancreatic surgical margin. Recurrence of SPN was diagnosed, for which resection of the pancreatic body, tumor and spleen was performed. Pathologically, the specimen showed morphologically homogeneous epithelial tumor cells arranged in a pseudopapillary pattern. Immunostaining was positive for β-catenin and CD10, and consistent with SPN. We report a rare SPN case that recurred locally five times, with successful removal on each recurrence. The relevant literature is also discussed.
