A Perihilar Bile Duct Squamous Cell Carcinoma Treated by Left Hepatic Lobe and Caudate Lobe Resection, Subtotal Stomach Preserving Pancreatoduodenectomy, and Portal Vein Resection

Abstract

A 73-year-old man was found to have gallbladder enlargement by abdominal ultrasound examination. CT and MRI showed a perihilar bile duct tumor as a wall thickening with contrast effect. The patient was diagnosed as a perihilar bile duct cancer. Left hepatic lobe and caudate lobe resection, subtotal stomach preserving pancreatoduodenectomy, and portal vein resection was performed. Histopathological examination revealed the keratinocytes tendency of the tumor. Immunohistochemical examination of the resected specimen revealed the expression of CK5/6 and p63 as a squamous epithelial marker. In addition, the component of adenocarcinoma could not confirm in this tumor. Therefore, the tumor was finally diagnosed as a squamous cell carcinoma of the perihilar bile duct. The patient is alive without recurrence for 45 months after surgery.