1990 Volume 23 Issue 3 Pages 695-704
Experimental studies were carried out to investigate the effect of ileo-jejunal transposition (UT) upon the secretion of gastric acid and gastrointestinal hormones. UT, sham 1 operation and sham 2 operation were constructed in 16 Heidenhain pouch dogs and the following results were obtained. 1) Following UT hyperenteroglucagonemia was observed. 2) The integrated gastrin resopnse and acid output from Heidenhain pouch after test meal loading were markedly elevated in the UT group. 3) The plasma gastric inhibitory polypeptide (GIP) levels at 60 to 90 minutes after the test meal were significantly decreased in the UT group. In conclusion, hyperenteroglucagonemia and a marked rise in gastric acid output were observed after UT. These observations do not support the idea that enteroglucagon has an enterogastrone effect. The release of GIP was not found to be affected by hyperenteroglucagonemia
