Abstract
It has been mentioned by many investigators that the infective larvae of Ancylostoma duodenale can easily come to maturity in human hosts by per stomachic infection, however, those of Necator americanus are scarecely possible to develop through the stomach.
In this study reported here, experimental infections through the stomach were carried out to 5 volunteers, without history of previous hookworm infection, for the purpose of making clear the main infection route of hookworms to human bodies and the cause of the difference of infectivity between larvae of Ancylostoma duodenale and those of Necator americanus in the stomachic infection to human hosts. Furthermore the larvae used in this study were not simply infective larvae, but were larvae that still stayed in ratskins for 24 or 48 hours.
But in this investigation, though larvae of Ancylostoma duodenale succeeded in the infection, those of Necator americanus failed. From this result, the auther guess that the establishment of stomachic infection to human hosts with larvae of Necator americanus is very difficult, and their infection ability can not increased from staying in ratskins. When the larvae migrate in human bodies, the auther imagines that it is necessary to pass through the lunge for accomplishment of infection.
