Abstract
The effects of oral administration of glutamic and aspartic acids on ammonia metabolism under the noise or the cold condition were observed in brain, liver, and blood.
The adult male rats were administered 5mg of each of these amino acids per 100g of body weight for 10 days before the exposure to noise or cold. The procedures were carried out as in the previous report except for the administration of these amino acids.
Under the noise condition, in the method of fixing the brain in situ by immersing the whole animal in coolant, the increase in the ammonia content of brain was not observed by the administration of each of these amino acids. In the method of decapitating, however, the ammonia content of brain was significantly higher than that of the control group, but the degree of increase was evidently reduced in comparison with the non-administration.
Under the cold condition, the ammonia content of brain was not affected by these administration.
The animals given aspartic acid showed the decrease in the ammonia content of liver and blood under the noise and the control condition, further of blood under the cold condition in comparison with the non-administration. But the administration of glutamic acid caused no changes in the ammonia content of liver and blood under each of these conditions.
