Abstract
In February 1962, in Miyazu city of Kyoto Prefecture, a food poisoning event occurred which closely resembled globefish poisoning. According to Dr. Hobo's epidemiological investigation a conclusion was reached that the food directly connected with the poisoning was the oyster which had been cultivated in Miyazu Bay.
An experiment was conducted to clarify the cause of this poisoning and the following results were obtained.
1) The poisonous component of the oysters was soluble in water.
2) This component was found in abundance in the internal organs, and the potency was lost by boiling in alkali.
3) The purified poison which was extracted with methanol and a purified method performed with ion exchange resine, charcoal and cellite had lethal doses of aproximately 1.2μg for 20g mouse parentally administered.
4) The poison was slightly different from the paralytic shellfish poison of mussel and Akasaragai as well as that of the globefish.
