Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
Online ISSN : 1882-6482
Print ISSN : 0021-5082
ISSN-L : 0021-5082
Experimental Studies for the Effect of 95Zr-95Nb to Albino Rats (Report 2)
Distribution of 95Zr-95Nb among Organs and Excretion of Them which Were Orally Administered to Rats
Toshiko Morishige
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1968 Volume 23 Issue 2 Pages 247-251

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Abstract
As previously reported, 95Zr-95Nb were detected in fallout and also in vegetation in the Fukuoka Prefecture even at other times besides occasions of nuclear explosion. It is suggested that an intake of a considerable dose of these radioactive agents may occur in common daily dietary food. In succession of Report I, which described the distribution and excretion of these radioactive agents in subcutaneously injected rats, an oral administration in rats using intubation technique was carried out consecutively and the distribution and excretion of these radioactive agents were pursued by using a G. M.-tube counter.
1) Radioactivities of every observed organ other than the stomach revealed the maximum value at the 24th hour after the administration, rapidly reduced up to the 7th day and very slowly decreasing.
2) A remarkable deposition of 95Zr-95Nb in tibia as distinguished from other organs was not observed in early stages after the oral administration although it differed from the former subcutaneous injection. But on the 63th day after administration, an amount of deposition of 95Zr-95Nb in second place after the spleen, was detected in the tibia.
3) The amount of 66.22% of the total excretion of 95Zr-95Nb was excreted by the 7th day after administration and also was measured in feces more than in urine. From the fact mentioned above, it is considered that 95Zr-95Nb given by oral administration to rats may have poor absorption by the alimentary tract.
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© The Japanese Society for Hygiene
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