抄録
A study of the in vitro and in vivo effects of cadmium on rat liver enzymes showed:
1) The addition of cadmium (10-4 M) to liver homogenate resulted in a marked inhibition of Na-K-Mg-dependent ATPase, but had no effect on Mg-dependent ATPase or transketolase.
2) When 2.5 or 5 μg of cadmium was administered to rats twice a week for three months, their liver Na-K-Mg-dependent ATPase activity decreased significantly, but there was no significant change in Mg-dependent ATPase or transketolase activity.
3) Separation of the livers of cadmium treated rats into subcellular fractions (i.e. nuclei, mitochondria, microsomes and supernatant) showed that about 80% of the cadmium was in the acid soluble fraction of the supernatant.
