Abstract
This investigation aimed at examining the hypertriglyceridemia induced by cobalt chloride may have some relationship with the increased plasma insulin and blood glucose level. The transitory rise of blood glucose at 2 hours after the intravenous injcation of cobalt chloride was synchronous with the increased level of blood insulin. Injection of cobalt chloride could not bring about higher concentration of plasma FFA than that of control rabbits, while at 24 hours after the injection, about a twentyfold increase of plasma triglyceride was observed accompanied by an accumulation of triglyceride in the liver. Hepatic α-glycerophosphate content was significantly already higher at 2 hours and this persisted for 24 hours whereas at 24 hours blood glucose returned to normal level with a slightly higher blood insulin level.
Despite increased level of blood insulin, no significant change could be observed in hepatic cyclic AMP content at 2 hours and there was not very much change in hepatic lysosomal triglyceride lipase activity at 24 hours after the injection. Therefore, hypertriglyceridemia observed in the cobalt-treated rabbit may be caused not by insulin induced inhibition of lipolysis in existing hepatic triglyceride.
