The Adjuvant Activity of Beryllium

Shogo Shima; Kunihiko Morita; Yoshiyuki Murai; Hiroshige Taniwaki; Yoshinobu Yamamoto; Shigeki Inoue

doi:10.1265/jjh.40.849

Shogo Shima, Kunihiko Morita, Yoshiyuki Murai, Hiroshige Taniwaki, Yoshinobu Yamamoto, Shigeki Inoue

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Keywords: Beryllium, Adjuvant, IgM-plaque forming cell, Humoral immunity

JOURNAL FREE ACCESS

1985 Volume 40 Issue 5 Pages 849-854

DOI https://doi.org/10.1265/jjh.40.849

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Abstract

The adjuvant activity of beryllium in two immune responses was examined in mice and guinea pigs. The splenic IgM-plaque forming cells in mice intraperitoneally or intravenously injected with beryllium chloride were significantly increased in comparison with that of the control mice. The induction of delayed type hypersensitivity to azobenzene-arsonate-N-acetyl-tyrosine was not increased by the injection of beryllium.
It was concluded that the adjuvant activity of beryllium was recognized on the humoral immune response.

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