Abstract

It has been experienced that the modified grading of mode of invasion (Yamamoto & Kohama) at the tumor-host borderline in oral squamous-cell carcinoma was closely correlated with effect of cancer-chemotherapy and survival rate of patients who had underwent surgery. The more tumor cells wers invasive, the more hyposensitive to anti-cancer agents these cases were and poor prognoses of patients were observed. According to these results, type-oriented induction chemotherapy consisted of two regimens has been applied in our Department from 1988. Regimen I (R-I) is OK432+BLM as mild chemotherapy for less-invasive cases of modes 1 and 2 of cancer invasion. On the other hand, Regimen II (R-II) is CDDP+PEP as strong one for more invasive cases of modes 3, 4 C and 4D of it. These regimens were applied for 21 cases of previously untreated oral cancer. Results were as follows: objective response rate in each regimen was 5/10 (50%) in R-I and 7/11 (63.6%) in R-II. Among five complete response cases, four were observed in less-invasive cases of M-1, 2 by mild chemotherapy of R-I. It was suggested from these results that sensitivity to anti-cancer agents of each case would be predicted and optimal chemotherapy regimen could be chosen at the time of pretreatment.