Abstract
Clinical and immunological effect of local immunochemotherapy combining cisplatin (CDDP) and recombinant Interleukin-2 (rIL-2) for head and neck cancer was studied. CDDP was administered by balloon occuluded arterial infusion (BOAI) through superficial temporal artery and subsequently, rIL-2 was administered by peritumoral injection or arterial infusion. Of twelve cases including oral cancers, mesopharyngeal cancers and maxillary cancers, five complete response (CR) and four partial response (PR) was achived. Effective rate was 75% and no sev ere toxicity was encounted.
Histological study revealed that marked lymphocytes infiltration was observed in tumor tissues of effective cases. Phenotypic analysis of peripheral blood lymphocytes exhibited an increase of CD4+ CD45R- cells and CD 25+ cells in these cases.
It will be documented that induction immunochemotherapy combining CDDP and rIL-2 could be one of beneficial treatments in a multidisciplinary treatment for these cancers.
