Abstract
To compare the efficacy and toxicity of CDDP-5-FU chemothetpy (CF) and CDDP-peplomycin chemotherapy (CP) for head and neck squamous cell carcinoma, retrospective statistical analysis was done. For regimen CF, CDDP was administered 70mg/m2 at day 1 and 5-FU was administered 700mg/m2/day at day 1-5. For regimen CP, CDDP was administered 50mg/m2 at day 1 and peplomycin was administered 5mg/body/day at day 2-6.
Of 153 cases applied to either CF or CP from April, 1981 to December, 1995, 139 cases were evaluable for response and toxicity. In 54 cases applied to CF the response rate was 72.2% (CR 12 and PR 27), while in the 85 cases applied to CP it was 68.2% (CR 22 and PR 36). According to each primary site, in oropharynx, the response rate with CP (88.9%) was higher than with CF (72.7%). Contrary in oral cavity, the response rate with CF (66.7%) was higher than with CP (54.5%). However, there were no significant differences statistically between CF and CP. The incidences of nausea and vomiting, leukopenia and thrombocytopenia were significantly higher with CF than with CP (p<0.01). However, the above toxicities were clinically mild and transient.
To increase the response rate of these combination chemotherapy, it is necessary to establish the method to select the optimal drugs based on each sensitivity for individual patient.
