Abstract
Cyclic-AMP (3', 5'-cyclic adenosine monophosphate) takes an important role as second messenger of signal communication system in a nerve cell of nevous system. It is known that the mutant of DrosophilaMelanogaster (dnc-) has obstaclein dunce (dnc) gene deficit, and evasion from hatred stimulation becomes inability. This dnc gene has phosphodiesterase (PDE) which c-AMP is resolved and is equivalent to phosphodiesterase type IV in Mammalia (PDE IV). In this study, I did fundamental experiment of rat PDE IV activity measurement using high perfromance liquid chromatography and measured the medicine long term dosage to beat against successively or a change of PDE IV enzyme activity in rat brain by electroconvulsive seizure. This enhance of PDE IV enzyme activity was recognized in sinciput domain by these measures. This is considered feedback mechanism by quantity of c-AMP increase to have been induced.
