Abstract
Four strains of Candida utilis (No. 1, No. 2, No. 3, and ATCC 9550), one of the industrial yeasts, were examined for the pathogenicity or virulence on mice in comparing with those of Saccharomyces cerevisiae ATCC 9763 and Candida albicans KULM 5012.
Saline suspension of 5×106 or 1×107 yeast cells of the organisms were inoculated intravenously to ddY male 4 weeks conventional mice. The same strain of 4 weeks SPF mice pretreated with 6MP or predonisolone were also used for the experimental infections. A total of 290 mice were studied.
From the results obtained from examinations of somatic signs, body weight curve, mortality rate, recovery culture from various organs, viable yeast cell counts in the liver, and extensive histopathological investigations, it was concluded that no remarkable difference in pathogenicity or virulence on mice was detected among 4 strains of C. utilis and 1 strain of S. cerevisiae ATCC 9763 in contrast to apparently virulent C. albicans KULM 5012.
