Abstract
The in vitro antifungal activity of SS717, a new topical imidazole, was studied in comparison with bifonazole (BFZ) using an agar dilution technique.
The SS717 activity toward several yeasts and molds was the highest in neutral medium, but it was lowered by an increase of inoculum size, prolongation of the incubation period and the addition of calf serum to the medium. Composition of the culture medium also significantly altered the activity of SS717. It exhibited a greater activity on casitone agar (CA) and brain heart infusion agar than on Sabouraud dextrose agar (SDA). Such a difference in SS717 activity between the two media was clearly observed in yeast-like fungi: the MIC values against clinical isolates of Candida albicans were from 10 to >20 (μg/ml) on SDA and from 0.63 to 10 (μg/ml) on CA. SS717 exhibited antifungal activity toward a wide range of pathogenic fungi, including those causing dermatophytoses and other superficial mycoses to a similar or greater extent than did BFZ.
