Inhibitory Effect of NND-318 on Ergosterol Synthesis in Trichophyton mentagrophytes and Candida albicans

Tetsuto Ohmi; Sadayoshi Sakumoto; Yoshimi Niwano; Hideki Oka; Takashi Suzuki; Matazaemon Uchida; Hideyo Yamaguchi

doi:10.3314/jjmm.33.349

Inhibitory Effect of NND-318 on Ergosterol Synthesis in Trichophyton mentagrophytes and Candida albicans

Tetsuto Ohmi, Sadayoshi Sakumoto, Yoshimi Niwano, Hideki Oka, Takashi Suzuki, Matazaemon Uchida, Hideyo Yamaguchi

Author information

Keywords: mechanism of action, inhibition of ergosterol synthesis, NND-318

JOURNAL FREE ACCESS

1992 Volume 33 Issue 3 Pages 349-354

DOI https://doi.org/10.3314/jjmm.33.349

Details

Abstract

To clarify the mode of antifungal action of NND-318, a new imidazole antimycotic, the effect of the agent on ergosterol synthesis in Trichophyton mentagrophytes and Candida albicans was examined, and compared to that of bifonazole.
NND-318 was found to interfere with ergosterol biosynthesis by inhibition of sterol C-14 demethylation. In terms of drug concentrations exerting 50% inhibition of ergosterol biosynthesis, NND-318 was ≥25 times stronger than bifonazole.

Corresponding author

Register with J-STAGE for free!