Effect of Carrier Solvents on the Efficacy of Oral Itraconazole Therapy in Aspergillosis in Mice

Abstract

During our studies on the efficacy of oral Itraconazole (ITZ) against Aspergillus fumigates infection in mice, we found that ITZ dispersed in a non-ionic detergent (HCO-60 vehicle), was not effective in the treatment of the infection, although amphotericin B and fluconazole solubilized in the same carrier were. Further studies revealed that the efficaciousness of ITZ in mice is mainly dependent on the solvent used as a carrier. Hydroxypropyl-β-cyclodextrin was the most beneficial carrier solvent, and polyethylene glycol was a less effective carrier.