It is very important for the proton therapy to detect the transmission length of oroton beam in a patient's body to verify the irradiated field. We measured activities of positron-emitters in water and MiX -DP bombarded by proton beam (experimental irradiation conditions; dose rate: 5cGy/min, dose: lGy). As a result of this experiment, it was suggested that it was possible to estimate the transmission length of protons from the depth-activity distribution in the region of depth deeper than the maximum activity depth, which decreased exponentially with depth. The activities in water and MiX DP immediately after bombarment by protons with an energy of about 130 MeV were about 1.6kBq/g and 1.2kBq/g, respectively. Immediately after bombarment, the main sources of the activity were 15O and 11C.