DNP-MRIを用いた放射線照射によるフリーラジカルの可視化［大会長賞記録］

抄録

　The purpose of this study was to detect free radical generation induced by X-ray irradiation using dynamic nuclear polarization (DNP)-MRI. The Electron Spin Resonance (ESR) signal intensity of the capillary, including that of Tempol and glutathione (GSH), decreased after X-ray radiation therapy. The reduction in the Tempol radical was dependent on the irradiation dose. The gel phantom, including Tempol, GSH, and 1% agarose, were clearly visualized radiation dose and trajectory using DNP-MRI. These results suggest that the DNP-MRI/Tempol gel method might be a useful technique for the visualization of X-ray irradiation.