Clinical Evaluation of Irsogladine Maleate for Oral Lichen Planus

Abstract

Oral lichen planus (OLP) is a relatively common disorder of unknown etiology in the oral mucous membrane.
We evaluated the clinical effectiveness of Irsogladine maleate (IM) on 18 patients with oral lichen planus. IM enhances the function of intercellular communication through gap junctions. The results were as follows: There was a predominance of female patients (66.7%). The largest number of cases were aged between 50 and 69 (over 70%). The location of the lesion was most commonly at the buccal mucosa followed by gingiva, lip and tongue.
Subjective symptoms improved in 13 patients (72.2%), and objective findings improved in 10 patients (55.6%). The reticular type showed the best response in this study.