Experimental radiosensitizer therapy for malignant tumor transplanted to nude and conventional mice

(1) Radiosensitive effect of misonidazole for Ehrlich solid carcinoma

Abstract

The host immunoactivity has related effects of surgical-, radio-, chemo-therapy of malignant tumor.
Then, this time, tumor growth delay effect of radiosensitizer misonidazole (MISO) was investigated by Ehrlich solid carcinoma bearing conventional ICR mice and nude ICR mice.
Carcinoma cells were transplanted into the right thigh of each mice.
The mice were divided into 3 groups i. e.(1) control group, (2) ⁶⁰Co 15 Gy local single radiation dose group, (3) MISO 20mg+⁶⁰Co 15 Gy combination therapy group.
There were no significant differences in tumor growth between conventional mice and nude mice on control group.
In Cobalt-⁶⁰Co 15 Gy single radiation dose group of conventional mice were retarded tumor growth but nude mice tumor were not.
On MISO 20mg+⁶⁰Co 15 Gy combination therapy, tumor growth was more retardative than single radiation dose on conventional and nude mice.
In conventional mice, ⁶⁰Co 15 Gy single radiation dose therapy was more effective than MISO 20mg+⁶⁰Co 15 Gy combination therapy in nude mice.