Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 31, Issue 8
Displaying 1-27 of 27 articles from this issue
  • (1) Radiosensitive effect of misonidazole for Ehrlich solid carcinoma
    Kazuo SAKAIZUMI, Shigeru SENUMA, Kazuhito SATO, Tetsuo NAGAI, Masami F ...
    1985 Volume 31 Issue 8 Pages 1827-1833
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The host immunoactivity has related effects of surgical-, radio-, chemo-therapy of malignant tumor.
    Then, this time, tumor growth delay effect of radiosensitizer misonidazole (MISO) was investigated by Ehrlich solid carcinoma bearing conventional ICR mice and nude ICR mice.
    Carcinoma cells were transplanted into the right thigh of each mice.
    The mice were divided into 3 groups i. e.(1) control group, (2) 60Co 15 Gy local single radiation dose group, (3) MISO 20mg+60Co 15 Gy combination therapy group.
    There were no significant differences in tumor growth between conventional mice and nude mice on control group.
    In Cobalt-60Co 15 Gy single radiation dose group of conventional mice were retarded tumor growth but nude mice tumor were not.
    On MISO 20mg+60Co 15 Gy combination therapy, tumor growth was more retardative than single radiation dose on conventional and nude mice.
    In conventional mice, 60Co 15 Gy single radiation dose therapy was more effective than MISO 20mg+60Co 15 Gy combination therapy in nude mice.
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  • Yasunori TOTSUKA, Hiroyuki NAKAMURA, Shigeru OYAMA, Kanchu TEI, Takeyu ...
    1985 Volume 31 Issue 8 Pages 1834-1840
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The purpose of this study is to clarify the usefulness of CO2 laser in Oral and Maxillofacial Surgery. The CO2 laser surgery was performed on 24 patients of oral cancer and 22 patients of oral benign diseases at the Oral Surgery of Hokkaido University Dental Hospital between 1981 and 1984.
    The results arc as follows: The CO2 laser surgery seemed to be very effective in Oral and Maxillofacial Surgery because it's hemostatic ability and visualization of the operative field make the operation precisely. For the best application of CO2 laser,
    1) Retractors and traction sutures must be used precisely in order to keep the operative field.
    2) The operative field must be dry and the vessels larger than 0.5mm in diameter must be coagulated by ligation or electrocauterization.
    3) It seems to be the best that the power of laser is set with the range from 5 to 10 watt and the spot size is adjusted to the diameter from 0.5 to 3.0mm as defocused beam.
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  • Ryuichi KAWASHIMA, Tadamitsu KAMEYAMA, Kiyomoto KITA, Yutaka YAKEISHI, ...
    1985 Volume 31 Issue 8 Pages 1841-1845
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    In a SEM finding, line structures were observed on the surface of salivary stones. This study determines whether line structures are microorganism.
    The materials are 19 submandibular gland calculi. Bacterium are isolated from the surface of calculi and cultured.
    The surface of all calculi and the isolated bacterium are observed by SEM.
    The results of isolated bacterium were 7 Streptococcus sp., 2 Corynebacterium sp., 1 Staphylococcus sp. and 1 Actinomyces sp.
    In a SEM finding of the surface of calculi, line structures were recognized in 4 cases, and from a case of them, Actinomyces sp. were isolated.
    The SEM finding of Actinomyces sp. and line structures of calculus surface were morphologically the same.
    On the other hand, we observed by clectron microscopy the scratched materials of the calculus surface which were isolated Actinomyces sp. and recognized that they were microorganism.
    The results described above suggest that the line structures of the calculus surface by SEM is Actinomyces sp.
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  • Yoshiaki YURA, Hiroki IGA, Kazuyoshi TERASHIMA, Hideo YOSHIDA, Tetsuo ...
    1985 Volume 31 Issue 8 Pages 1846-1853
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    Recurrent intraoral herpes simplex virus infection, which was first described by Griffin in 1965, is an uncommon type of herpes simplex virus (HSV) infection. To determine whether this is caused by reactivation of HSV in the oral cavity latently infected with HSV, we isolated the viruses from primary and recurrent lesions of intraoral HSV infection in the same patient and analyzed the DNA of the isolated HSV viruses.
    A 48-year-old woman came to our clinic on July 15, 1982 with severe pain in the oral cavity. On examination, numerous ulcerative lesions were observed in the mucosa of lower alveolus and hard palate. HSV was isolated by tissue culture work from the swab of lesions. Although the antibodies against HSV were not detected by complement-fixation test in the serum harvested from the patient at acute phase of the disease, the titer was increased to ×16 at the convalescent stage. Therefore, it was diagnosed as a primary herpetic gingivostomatitis. This disease was healed completely by topical administration of interferon-β. About 11 months later, ulcerative lesions occurred again in the lower gum and were treated with interferon-β. Virus was isolated from the lesions and proved to be HSV as demonstrated by a fluorescent antibody staining method for HSV antigen.
    The two isolates obtained at different time from this patient, including standard HSV type 1 and 2, were grown in Vero cells. DNA was extracted from the infected cells according to the method of Hirt and was digested with various restriction endonucleases. The DNA fragments were submitted to agarose gel electrophoresis, stained with ethidium bromide and then the electrophoretic patterns were observed under UV illumination. The cleavage pattern of DNA from all the HSV isolates was found to be similar to that of HSV type 1, but not to the HSV type 2. Therefore, these isolates can be considered to be HSV type 1. Moreover, the two viruses isolated from the present case gave almost same DNA cleavage pattern. From these findings, it can be concluded that the intraoral HSV infection which occurred after complete remission of the primary HSV infection in the present case is caused by the same virus, implying that the second onset of intraoral HSV infection is of recurrent form.
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  • Keiichi KAWAI, Hideharu SUZUKI, Toshio KANEDA, Tohru OKA, Keizou SATO, ...
    1985 Volume 31 Issue 8 Pages 1854-1858
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Hemostatic condition after oral surgery is now confirmed by subjective methods such as visual observation or listening to patient's complaints. Quantitative analysis of intraoral hemorrhage, however is desirable for the postoperative managment, especially in cases of hemophilia or other coagulopathies. Although determination of hemoglobin concentration in saliva is useful for this purpose, the cyanmethemoglobin method, the internationally standardized method for the determination of hemoglobin in blood, is not suitable for the determination of low concentration of hemoglobin. In this study, a modified cyanmethemoglobin method was devised for the determination of low concentration of hemoglobin. An absorption maximum at 420nm having high molecular extinction coefficient was chosen for the determination of cyanmethemoglobin concentration in the present method, and sample volume was increased ten-fold. Thus, the sensitivity was increased approximately 100-fold in this method, and hemoglobin concentration could be correctly determined even in 1000-fold diluted blood with saline. The use of half-diluted saliva as a diluent showed a little effect on the values of hemoglobin concentration. Although further study is necessary for sampling and/or storage of saliva contaminated with blood, the present method appears to be useful for quantitative analysis of intraoral hemorrhage.
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  • Natsuki SEGAMI
    1985 Volume 31 Issue 8 Pages 1859-1870
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Extraction sockets of the dog were examined tridimensionally with a scanning electron microscope in order to clarify the process of blood clots transform action into bone in osseous repair. Excellent observation was able to be made only when total perfusion of the head-neck and cracking with styrene resin were utilized.
    On postextraction days 1-2, sockets were filled with clots of red blood cells and fibrin networks. By the second day, fine fibrils of 0.1 μm in diameter had appeared, twisting around fibrins and rapidly increasing in amount. Collagen fibers of 0.4-0.6 pm in diameter which started to appear on the 4 th day, became predominant and replaced the former fine fibrils by the 7 th day, by which time the original clots had been completely transformed into fibrous tissue masses. In addition, on the 7 th day, osteoblasts began to appear in this sea of collagns. Apposition of calcospherites were also observed on some collagen fibers near these osteoblasts. Between the 14 th and 21 st day after extraction, calcospherites measuring 0.3-0.5 pm in diameter gradually filled the intercollagenous spaces to form the bony matrix. X-ray microanalysis of these calcospherites confirmed the presence of calcium and phosphorus. By postextraction day 30-60, well-formed lamellar bony trabeculae with Haversian systems had appeated, and this completed osseous repair of the socket.
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  • Michitoki KINEHARA
    1985 Volume 31 Issue 8 Pages 1871-1886
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    In this study, analgesic and sedative effects of pentazocine and diazepam were examined both with the suppression rate indicated by a new experimental method (Murayama et al.) of measuring pain response and with their clinical applications. A pair of electrodes were implanted into the pulp of each lower incisor of rabbits. After a week, the pulp was electrically stimulated through the electrodes in order to elicit the pain response. When the suitable stimulation was given, the movement corresponding to the intensity appeared in the lower jaw. The responses were recorded on oscillograph using a tension transducer. Since these movements were dose-dependently suppressed with morphine, each suppression degree correlated directly to that of analgesic condition. Based on this fact, the effects of pentazocine, diazepam and pentazocine-diazepam combination were examined. All drugs were administered intravenously. 1) Pentazocine of 4mg/kg acted similarly to morphine of 2mg/ kg for 90 minutes. 2) Combined application of pentazocine of 4mg/kg and diazepam of 0.4mg/kg showed similar effect to morhine of 4mg/kg for 90 minutes. 3) No analgesic effect appeared with a single usage of diazepam. Clinically, intravenous administration of pentazocine with diazepam brought about psychosedative condition on surgically treating patients. After the administration of pentazocine (0.6mg/kg) and diazepam (0.2mg/kg), sedative effect was obtained in 76.7 percent of cases. Although pulse rate was slightly increased, no significant change of blood pressure was observed. Concerning to the respiratory function, its slight suppression was observed, but clinically no treatment was required for it. Nausea and vomiting were seen in 11 cases (7 percent). In conclusion, the intravenous combined application of pentazocine and diazepam has a preferable analgesic and sedative effect for local anesthesia.
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  • Ken HASEGAWA, Shen-Wen LIN, Yoichi HAMASAKA, Takeshi HONDA, Katsuma KO ...
    1985 Volume 31 Issue 8 Pages 1887-1892
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Ranula is a term to indicate rather roughly a mucous retention cyst occurring in the floor of mouth, which is caused by passing disorder of saliva in the submaxillary duct or sublingul one. The developmental mechanism of the most of ranula is known to be salivary extravasation from an injured duct, whose cause is most commonoly described as trauma, followed by inflammation, foreign body.
    This report describes a case of ranula whose development should be concerned with sialolithiasis.
    The patient, a 40-year-old man, visited us with a chief complaint of a swelling on left side of the floor of mouth. Radiographic examination revealed sialoliths in the left submaxillary duct and gland. The fenestration of ranula was carried out, the sialoliths were extirpated.
    It should be thought, in this case, that saliva was extravasated into the connective tissue of the floor of mouth by the perforation of the submaxillary duct to which sialoliths were an injury.
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  • Koji TAKAHASHI, Hiroshi YOSHIDA, Hiroko TOKURA, Hiromichi AKIZUKI, Ken ...
    1985 Volume 31 Issue 8 Pages 1893-1904
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of adenomatoid odontogenic tumor with the impacted lateral incisor and cuspid in 11-year-old boy is presented and 89 cases of the tumor reported in our country are reviewed.
    After the excision of the tumor, two impacted teeth were moved successfully to thier normal position with orthodontic appliance.
    Histopathological findings of the tumor are as follows; two kinds of eosinophilic materials were stained similarly, and calcified materials seemed to be concerned with alkali-phosphatase positive cells.
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  • Madoka INUI, Toshirow TAGAWA, Hiroyuki KIHARA, Masaru TAKAHASHI, Shing ...
    1985 Volume 31 Issue 8 Pages 1905-1910
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    The developmet of squemous cell carcinoma in an old burn scar (burn scar carcinoma) of upper lip is reported.
    Various causes of burn scar carcinoma arc discussed and the immunological factor that reported a burn scar is immunologically privileged site is considered important.
    The status of cell-mediated immunity is examined in this case using lymphocyte blastoid transformation (blastogenesis) by PHA and Con-A.
    General immunosuppression was also seen and it tended to be elevated by PSK administration.
    The finding of general immunosuppression indused by large old burn scar is considered one of the factor of burn scar carcinoma.
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  • Takashi KITA, Kei SATO, Koji KAWATA, Miyo YOSHINARI, Noboru KANEMATSU, ...
    1985 Volume 31 Issue 8 Pages 1911-1916
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    We used Pepleomycin for 23 cases of oral cancer, and obtained following results.
    1) Anti-cancer effects were as follows: remarkably good in 4 cases, efficacious in 3 cases, slightly good in 13 cases, and none in 3 cases.
    2) The effects of Pepleomycin were remarkably good in carcinoma of the buccal mucosa, efficacious in carcinoma of the mandible, no significant in carcinoma of the maxilla and tongue, and none in recurrent carcinoma.
    3) Stomatitis were mostly noticed as side effects but pulmonary fibrosis was not induced.
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  • Toshiyuki YONEDA, Masaaki BESSHO, Noriyoshi NISHIKAWA, Ken MATSUMOTO, ...
    1985 Volume 31 Issue 8 Pages 1917-1924
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    Hypercalcemia and leukocytosis are paraneoplastic syndromes occurring in association with malignant diseases but are uncommon in head and neck cancers. In the present paper, we report a clinical cousrse of a patient with tongue cancer accompanying with not only hypercalcemia but leukocytosis. We also describe the results of experiments in which we studied the mechanisms involved in pathogenesis of hypercalcemia and leukocytosis.
    A 40-year-old man was seen in February, 1982 with a 2.1×1.8×1.2 squamous cell carcinoma (T2N0M0) on the right side of his tongue. He received irradiation and chemotherapy first and then a resection of his tongue, jaw and neck 11 months later. He remained well almost for 6 months but was readmitted to the hospital with the complaint of severe back pain. Computed tomography film demonstrated a bony metastasis in third or fourth lumbar spine. At that time, his serum calcium level was 16 mg/dl and white blood cell count was 18, 000/mm3. A hypocalcemic hormone calcitonin failed to reverse serum calcium level. Serum levels of calcium-elevating hormones including parathyroid hormone, active metabolite of vitamin D3 and prostaglandin E3 determined by radioimmunoassay were all within normal range.
    His serum serially purified by ultrafiltration, diafiltration and gel chromatography showed marked bone resorbing activity and colony stimulating activity. Peak activities of bone resorption and colony stimulation were eluted respectively at a molecular weight of approximately 20, 000 and 30, 000 dalton on Sephadex G-100 column. These activities were not detected in sera of other patients with cancer or acute inflammation and of normal individuals.
    It was suggested that these activities found in the serum of the patients reported here might be responsible for the hypercalcemia and leukocytosis.
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  • Kenjiro HIDA, Yoshimitsu KAMEYAMA, Nagayoshi YAMADA
    1985 Volume 31 Issue 8 Pages 1925-1929
    Published: August 20, 1985
    Released on J-STAGE: September 13, 2011
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    Branchial cyst is a comparatively rare disease of embryological interest, which is considered to be originated from the embryonal branchial apparatus. This cyst, which occurs preferably at the cervix positionally adjacent to the jaw and the oral cavity, is often questioned on its correlation with odontopathies.
    Recently, we have experienced a case of branchial cyst, which occurred at the right mandibular angle of a 20-year old woman.
    The patient, who became aware of some swelling at her right mandibular angle with pyrexia three months before her visit to our department, was diagnosed as something like epidemic parotids and submandibulr gland cyst, and received several suctions and punctures without success at other department, and then came to our department where she underwent its total resection. At present, she shows good prognosis without relapse. Histopathologically, diagnosis was definitely made as branchial cyst.
    In the present case clinical symptoms and findings in the resected specimens supposed that the pyrexia with unknown origin was partially responsible for the occurrence of the cyst. Subsequently, several suctions seemed to lead to the secondary infection, thus affecting the enhancement of the growth of the cyst. In terms of the differential diagnosis, We gave some literary considerations and reported above.
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  • Toshifumi ANDO, ISOO NOGUCHI, Fumio IDE, Masayuki TAKAHASHI
    1985 Volume 31 Issue 8 Pages 1930-1941
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    We recently have encountered a calcifying odontogenic cyst peripheral to the impacted tooth (8) of a 23-year-old female patint with the right maxillary sinus inflammation.
    Interestingly, the cyst accompanied with ameloblastomaous proliferation and adenomotoid odontogenic tumor-like proliferation, therefore, a pathologic study of this case along with a review of the literature is discussed in thsis paper.
    In the study of 69 cases of calcifying odontogenic cyst in japan, many were found to have impacted tooth (53.6%), mostly at the site of the canine (79.7%), and many had the complication of odontogenic tumor (43.9%).
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  • Hideki MATSUI, Tadahiko IIZUKA, Yasutomo SHIMIZU, Kenji KUSUMOTO, Yuki ...
    1985 Volume 31 Issue 8 Pages 1942-1947
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    This paper reports a case of branchiogenic fistula on the right side of the neck. The patient was a 15-year-old male with complaint of liquid-oozing from the orifice of the fistula in the right lateral cervical region. The diagnosis could be easily made by radiography with retrograde injection of radio opaque material through the external orifice of the fistula. The fistula exhibited complete lateral cervical type orignated from the second branchial pouch.
    The fistula was completely excised surgically under the general anesthesia. The following findings were obtained histopathologically:
    1. The inner surface of the fistula was covered with columnar ciliated epithelium.
    2. The lymphoid tissue and a thin layer of striped muscle were observed subepithelially.
    The embryologic mechanism and histopathological finding were discussed briefly and several literatures were reviewed.
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  • Masahiro NISHI, Tsutomu TANAKA, Takafumi UEMURA, Tamotsu MIMURA, Atsus ...
    1985 Volume 31 Issue 8 Pages 1948-1954
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    Oral leiomyosarcoma has been reported on only 21 cases in the literatures. An additional case of leiomyosarcoma of the maxilla is presented.
    A 32-year-old woman was reffered to our department from a certain medical college hospital. The pathological diagnosis on the biopsy stained with hematoxilin-eosin at the hospital was the poorly differentiated fibrosarcoma. Surgical resection was abandoned because the tumor invaded the left maxilla extensively from the palatal shelf to the base of skull. Chemotherapy with Adriamycin and Endoxan was performed, and the growth of tumor seemed to be suppressed. However the patient died in cachectic state 22 months after the onset.
    An autopsy demonstrated diffuse infiltration of the tumor into the medial cranial foxa and metastases in the lungs, liver, right cardiac ventricle and diaphragm. Submandibular and cervical lymphnode were free from metastasis.
    The autopsy specimen stained with Masson's trichrom, Azan and van Gieson revealed the characteristic structure showing which derived from smooth muscle cell. The diagnosis was ascertained as the leiomyosarcoma.
    The twenty-two previously reported cases of the oral leiomyosarcoma involving our case are reviewed, and the clinical features and the therapy on the tumor are discussed.
    The specific staining methods are useful in the diagnosis of this tumor. It is suggested that chemotherapy with Adriamycin is useful to enhance the effect of surgical resection and also to reserve the radical neck dissection after the manifestation of the regional lymphnode metastasis.
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  • Tsukasa NAGAMORI, Moritaka ENDO, Susumu OHMURA, Shigeru ONO, Kiyohide ...
    1985 Volume 31 Issue 8 Pages 1955-1958
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    We reported a case of an ectopic thyroid gland with cyst formation on the side of the neck. A 42-year-old male patient visited our hospital, complaining of a cherry-sized mass on the right side of the neck of 20 years' duration. This lesion was enucleated under local anesthesia. Microscopic finding revealed the thin fibrous cyst wall lined by a layer of cuboidal or flattened cells. A few thyroid follicles were seen in the capsule of the lymph node attached to the cyst. This was histologically diagnosed as an ectopic thyroid gland. The postoperative examinations revealed that the thyroid function remained within normal range and the normal thyroid gland was located in its normal anatomic position.
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  • I. Statistical analysis of the patients in recent five years
    Masamichi OHISHI, Sadako KAI, Tatsuyuki HAITA, Kaichiro HIGUCHI, Jinza ...
    1985 Volume 31 Issue 8 Pages 1959-1963
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A statistical analysis was made to the Patients of cleft lip over the age of five years who received secondary corrective operations at the Clinic of Oral Surgery, Kyushu University Hospital from January, 1979 to December, 1983.
    In these five years, secondary corrective operations were performed to 217 patients (241 cases), 51% of which were male patients and 49% were females. There were 100 patients (46%) who had received primary operations elsewhere.
    Most patients (94%) were between the ages of 5 and 29 years and the patients over 30 were few.
    Removal of the hypertrophic scar of the white lip was performed to 83% of the patients and 64% received the revision of nasal deformity.
    Operations were performed under local anesthesia in 29% and 71% of the patients were operated on under general anesthesia. When the operation was accompanied by the revision of nasal deformity, general anesthesia was used more often (81%), comparing with the opertion only on the white lip (40%).
    Twenty four percent of the patients were of bilateral cleft lip and 51% of which received corrective operations more than twice.
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  • Fumiko KUSHIRO, Teruyo FUKUDA, Tatsuo TSUJI, Masamichi IDA, Hitoshi TA ...
    1985 Volume 31 Issue 8 Pages 1964-1968
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We reported two cases of plunging ranulas. One of these eases is of an 11-year-old boy patient. From several months before, he had noticed. painless swelling in the right submaxillary region. He left it as it was because of no pain. However, it gradually increased in size, so he consulted our clinic and was admitted.
    We confirmed it by a sialogram and routine radiographic investigation, but there was no abnormality in the submandibular gland and its duct.
    Surgical extirpation was carried out from the right submaxillary triangle under general anesthesia. During the operation, the thin walled cyst sac ruptured, so the dissection of the lesion was extremely difficult. We tried to remove the cyst sac as soon as possible.
    The follow up examination was done one year and 4 months later and there was no abnormality.
    The other case is of a 29-year-old male patient whose physical examination disclosed a painless, diffused and soft cystic mass located in the left submaxillary area.
    The X-ray, computed tomography showed a clear mass in contact with the submandibular gland, which indicated 17 to 29 CT numbers.
    Surgical incision was made in the skin below the left submaxillary triangle. And we extirpated both the cyst and submandibular gland simultaneously. After the surgery, about a year and two months have passed and there is no recurrence.
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  • Koichi OGAWA, Yohko FUKUTA, Morio TOTSUKA, Yasunori TAKEDA
    1985 Volume 31 Issue 8 Pages 1969-1974
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    A case of median palatine cyst arising in a 28-year-old man with complaining of a midpalatal swelling was reported. Radiographic examination showed a small and round cystic radiolucent area in the middle palate. At the surgical operation, confirmatory evidence, both tooth-root and incisive canal were not involved in the lesion, was noted.
    In addition to the present case, clinico-pathological and embryological literatures of median palatine cyst were reviewed, though median palatine cyst has been neglected in the WHO classification of non-odontogenic cysts.
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  • Michio SHIKIMORI, Katsutoshi MOTEGI, Toru OKA
    1985 Volume 31 Issue 8 Pages 1975-1980
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    The incidence of malignant oral melanoma amounts to more than 10% of all malignant melanomas in Japan, which is higher than that reported by Conley and Park. This paper describes a case of malignant melanoma of the left mandible that resulted in disseminated metastases.
    A 31-year-old man presented at Nagoya University Hospital. First examination in Apr, 1977 revealed diffuse swelling and pigmentation of the left mandibular gingiva with ulceration of 5mm in diameter. The roentgenographic findings showed diffuse bone resorption in the left premolar and molar regions, presenting a pattern of horizontal bone resorption seen in periodontal diseases.
    Excision of the tumor was performed with partial dissection of the right neck and total dissection of the left neck. This surgical intervention was followed by chemotherapy with 5-Fu, MMC and EX. Histopathologically the tumor was localized at the primary site without other tumor lesion in regional lymphnodes (pT4pN0pM0, stage 1b).
    In Apr, 1978 skin metastasis was found. It soon began to develop into multilesional, extensive subcutaneous metastases. The metastatic lesions responded completely to immunotherapy with local BCG. However, the administration of BCG by multiple puncture tine technics produced no effect.
    From Nov, 1978 when lung metastasis was detected until Feb, 1980 when brain metastasis was detected, immunotherapy failed to produce any remarkable change in the metastatic tumors. By chemotherapy consisting of 12 courses of DTIC, Me-CCNU and hydroxyurea over 15 months, partial response such as reduction of the tumor size and depigmentation was obtained at each course. However, any tumor disappeared. By the end of this period, despite increase in the number and size of the metastatic tumors, the behavior of the malignant melanoma was subdued.
    In Feb, 1980 he complained of headache and brain metastasis was detected by CT-scan. In spite of ACNU and THFT therapy, the patient died with complications of DIC and DM on May 26, 1980, 3 years and a month after his first visit.
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  • Kazuo TAKADA, Fukashi ADACHI, Ryuichi NEMOTO, Masami MISHINA, Shigesug ...
    1985 Volume 31 Issue 8 Pages 1981-1987
    Published: August 20, 1985
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    Clinical presentation and histologic observations of a combined epithelial odontogenic tumor which contained foci diagnostic for both calcifying odontogenic cyst (COC) and adenomatoid odontogenic tumor (AOT) were reported.
    Dreibladt, in 1907, first reported the adenomatoid odontogenic tumor (AOT) and Stafne separated it as a distinct of odontogenic tumor. The calcifying odontogenic cyst (COC) was presented as a distinct by Gorlin and his colleagues in 1962. These two different odontogenic lesions have not been reported previously as occurring simultaneously.
    A 71-year-old man was admitted on Nov. 15, 1983 with progressive swelling of the maxilla. Radiographs showed radiolucent lesion, but did not present an impacted tooth in the area of the lesion. The tumor was removed by partial maxillectomy.
    Histologic observations were revealed that the tumor consisted of four types of cells: odontogenic epithelial cells with ghost cells, low columner adenomatoid cells, proliferative odontogenic epithelial cells and spindle flattened cells. These findings strongly supported the hypothesis that COC and AOT may originate from odontogenic epithelia of the tooth bud.
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  • Nobuo TAKANO, Yoshimi ICHINOKAWA, Junichi TANAKA, Yoko NAKANO, Kiyohik ...
    1985 Volume 31 Issue 8 Pages 1988-1993
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
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    Leiomyoma may occur anywhere in the human body which has smooth muscle. It is most commonly found in the uterus, gastrointestinal system and subcutaneous tissue. However, leiomyoma in the oral cavity is uncommon. We recently experienced a case of solid leiomyoma in a 12-year-old girl, which was arised from gingiva of upper molar region and developed into maxillary sinus. Only 11 cases including ours of leiomyoma in the oral region have been so far reported in our country.
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  • Takehiko IIJIMA, Hiromichi ITO, Tsuneto OWATARI, Nagaaki SUZUKI, Yasuy ...
    1985 Volume 31 Issue 8 Pages 1994-1999
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Two cases of DIC accompanied by oral cancer arc presented.
    Case 1: 35-year-old-male was diagnosed of pre-DIC because the examination data of coagulation and fibrinolysis were abnormal. By gabexate mesilate (1, 800mg/day) administration, they changed for the better.
    Case 2: 66-year-old-male was diagnosed of acute DIC because of hemorrhagic tendency and MOF (multiple organ failure). He fell in renal, hepatic, respiratory failure and mechanical ventilation was immediately given. By the administration of gabexate mesilate (1, 600 mg/day), methylpredonisolone and prostaglandin E1, the findings of the coagulation and fibrinolysis were improved, subsequently his organic functions gradually became better.
    Gabexate mesilate, which was developed for the therapy of pancreatitis, has shown efficiency in the treatment of DIC. We gave it to the patients of DIC complicated by oral cancer, and we found it useful for DIC after the maxillofacial surgery.
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  • Toshihumi ISHIBASHI
    1985 Volume 31 Issue 8 Pages 2000-2004
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The author encountered a 60-year-old man, who had white patches on the left lateral border mucosa of the tongue and on the left antcromedial mucosa of the soft palate. The biopsy specimen of the tongue was diagnosed as early invasive squamous cell carcinoma. A year and six months after the enucleation of the tumor, a white patch appeared on the right lateral border mucosa of the tongue. Four year and four months later, this biopsy specimen was also diagnosed as early invasive squamous cell carcinoma. The author reported bilateral early cancer of the tongue because such a case could not be found in the literature in the oral cavity.
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  • Masaru HORIKOSHI, Satoshi ISHIDA, Mikio KUSAMA, Takashi FUJIBAYASHI, S ...
    1985 Volume 31 Issue 8 Pages 2005-2010
    Published: August 20, 1985
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    The presence of sebaceous glands in the oral mucosa is not uncommon, however, sebaceous elements are rarely found on the tongue. Only six cases of ectopic sebaceous glands of the tongue have been reported previously. And four cases of them which have formed duct-like structure were discussed in relation to the thyloglossal duct.
    We have recently encountered a case which was clinically and microscopically similar to the prior cases. In this article, a case report was presented with the review of the literature.
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  • Masasuke OHBA, Haruhiko SAKAMOTO, Noriko OTOZURA, Tatsuo KASAKURA, Aki ...
    1985 Volume 31 Issue 8 Pages 2011-2017
    Published: August 20, 1985
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Two cases of marsupialization for huge cyst of the jaw are reported in this paper.
    Case 1 was 31-year-old man who was referred by a dental clinic for extensive radiolucent area in the mandible. Oral examination revealed slight bony expansion on the buccal side of the mandible. Panoramic roentgenogram revealed a well-defined monocystic radiolucent area from 6 to 6. Electrical vitality test revealed nonresponse for 6 6. The clinical diagnosis was suspected an ameloblastoma. Under local anesthesia, marsupialization was performed considering the extraction of 65 56 with severe mobility, and then partial cystic tissue was removed from the cavity. The histopathological diagnosis was considered primordial cyst and not tumor tissue. Roentgenogram revealed that the area appeared semiradiopaque 6 months later and radiopaque with regeneration of bone 16 months after the operation. Electrical vitality test was responded to 4 4.
    Case 2 was a 52-year-old man who first noticed a swelling of the right maxilla before 4 days. Oral examination revealed bony expansion on the buccal side of the maxilla. Panoramic roentgenogram revealed a well-defined monocystic radiolucent area from 51 to 16 containing 3 and supernumerary tooth. Electrical vitality test revealed no response for 5421 2345. The clinical diagnosis was suspected follicular cyst. Under local anesthesia, marsupialization was performed considering the extraction of 3 and 5421 with severe mobility, and then partial cystic tissue was removed from the cavity. The histopathological diagnosis was considered folicular cyst and not tumor tissue. Roentgenogram revealed that the area appeared semiradiopaque 3 months later and radiopaque with regeneration of bone 18 months after the operation. Electrical vitality test was responded to 45.
    No relapse occurred in either case after the operation.
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